San Lorenzo is located on the route of El Camino Viejo on land of the former Rancho San Lorenzo, a Mexican land grant given to Guillermo Castro in 1841, and the former Rancho San Leandro, granted to José Joaquin Estudillo in 1842.[9]
Early residents during the California Gold Rush era lived here as squatters along the border between Rancho San Lorenzo and Rancho San Leandro.[10] The informal name given to the area was Squatterville.[11]
The first post office opened in San Lorenzo in 1854.[12]
Many of the early inhabitants are buried in San Lorenzo Pioneer Cemetery, including Moses Wicks, who brought oysters to San Leandro Bay from Patchogue, Long Island.[13] The cemetery is maintained by the county and the Hayward Area Historical Society.
San Lorenzo was mostly farmland, a significant center of production of fruit and flowers, from the mid-19th century to the mid-20th century.
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